Inhibitors of apoptosis (IAP) protein family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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The Inhibitors of apoptosis (IAP) are a family of functionally and structurally related proteins. The human family has eight members: NAIP (BIRC1), BIRC2 (cIAPl), BIRC3 (cIAP2), XIAP (BIRC4), BIRC5 (survivin), BIRC6 (apollon), BIRC7 (livin) and BIRC8. All members of the family contain 1-3 copies of a 70-80 amino acid motif known as BIR (baculovirus IAP repeat). The IAPs have garnered interest as drug targets with antineoplastic [1,9] and immunomodulatory [3] potential. Small molecule, antagonistic, peptide mimetics have been described [5-6,8].

Targets

NLR family apoptosis inhibitory protein Show summary » More detailed page

baculoviral IAP repeat containing 2 Show summary » More detailed page

baculoviral IAP repeat containing 3 Show summary » More detailed page

X-linked inhibitor of apoptosis Show summary » More detailed page

baculoviral IAP repeat containing 5 Show summary »

baculoviral IAP repeat containing 6 Show summary »

baculoviral IAP repeat containing 7 Show summary »

baculoviral IAP repeat containing 8 Show summary »

References

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How to cite this family page

Database page citation:

Inhibitors of apoptosis (IAP) protein family. Accessed on 17/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=889.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Overview. Br J Pharmacol. 174 Suppl 1: S1-S16.