Regulators of G protein Signaling (RGS) proteins C

Overview

« Hide

Regulators of G protein signalling (RGS) proteins display a common RGS domain that interacts with the GTP-bound Gα subunits of heterotrimeric G proteins, enhancing GTP hydrolysis by stabilising the transition state [1-3], leading to a termination of GPCR signalling. Sequence analysis of the 20 RGS proteins suggests four families of RGS: RZ, R4, R7 and R12 families. Many of these proteins have been identified to have effects other than through targetting G proteins.

Subfamilies

Further reading

Show »

References

Show »

NC-IUPHAR subcommittee and family contributors

Show »

How to cite this family page

Database page citation:

Benita Sjögren, Kirk M. Druey, Rory A. Fisher, John R. Hepler, Shelley B. Hooks, Kirill Martemyanov, David L. Roman, Thomas M. Wilkie, Zili Luo, Hoa Phan Thi Nhu, Vincent Shaw, Yalda Zolghadri, Bandana Chakravarti, Laurie Sutton, Keqiang Xie. Regulators of G protein Signaling (RGS) proteins. Accessed on 17/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=891.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Overview. Br J Pharmacol. 174 Suppl 1: S1-S16.