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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Methyllysine reader proteins bind to methylated proteins, such as histones, allowing regulation of gene expression.
* Key recommended reading is highlighted with an asterisk
* Liu K, Liu Y, Lau JL, Min J. (2015) Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation. Pharmacol. Ther., 151: 121-40. [PMID:25857453]
* Musselman CA, Khorasanizadeh S, Kutateladze TG. (2014) Towards understanding methyllysine readout. Biochim. Biophys. Acta, 1839 (8): 686-93. [PMID:24727128]
* Thinnes CC, England KS, Kawamura A, Chowdhury R, Schofield CJ, Hopkinson RJ. (2014) Targeting histone lysine demethylases - progress, challenges, and the future. Biochim. Biophys. Acta, 1839 (12): 1416-32. [PMID:24859458]
Database page citation:
Methyllysine reader proteins. Accessed on 27/03/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=902.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Buneman OP, Catterall WA, Cidlowski JA, Davenport AP, Fabbro D, Fan G, McGrath JC, Spedding M, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Overview. Br J Pharmacol. 172: 5729-5743.