Serum pentaxins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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SAP is a member of the pentraxin protein family.

SAP [7] is a constitutively expressed vertebrate protein [9] found in all types of amyloid deposits [10-11], in glomerular basement membrane [3] and in elastic fibres in blood vessels [2]. SAP binding is calcium-dependent [8]. It is suggested that SAP binding may have an important role to play in atherosclerosis [6,12] and amyloidosis [1,14]. The identification of SAP as a player in amyloidoses and neuropathies, and in response to proof of concept studies [4], this protein is now a drug discovery target [5].

Targets

amyloid P component, serum Show summary » More detailed page

References

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How to cite this family page

Database page citation:

Serum pentaxins. Accessed on 29/04/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=907.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Buneman OP, Catterall WA, Cidlowski JA, Davenport AP, Fabbro D, Fan G, McGrath JC, Spedding M, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Overview. Br J Pharmacol. 172: 5729-5743.