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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
SAP is a member of the pentraxin protein family.
SAP  is a constitutively expressed vertebrate protein  found in all types of amyloid deposits [10-11], in glomerular basement membrane  and in elastic fibres in blood vessels . SAP binding is calcium-dependent . It is suggested that SAP binding may have an important role to play in atherosclerosis [6,12] and amyloidosis [1,14]. The identification of SAP as a player in amyloidoses and neuropathies, and in response to proof of concept studies , this protein is now a drug discovery target .
1. Breathnach SM, Bhogal B, Dyck RF, De Beer FC, Black MM, Pepys MB. (1981) Immunohistochemical demonstration of amyloid P component in skin of normal subjects and patients with cutaneous amyloidosis. Br. J. Dermatol., 105 (2): 115-24. [PMID:7025878]
2. Breathnach SM, Melrose SM, Bhogal B, de Beer FC, Dyck RF, Tennent G, Black MM, Pepys MB. (1981) Amyloid P component is located on elastic fibre microfibrils in normal human tissue. Nature, 293 (5834): 652-4. [PMID:7290201]
3. Dyck RF, Lockwood CM, Kershaw M, McHugh N, Duance VC, Baltz ML, Pepys MB. (1980) Amyloid P-component is a constituent of normal human glomerular basement membrane. J. Exp. Med., 152 (5): 1162-74. [PMID:7000964]
4. Gillmore JD, Tennent GA, Hutchinson WL, Gallimore JR, Lachmann HJ, Goodman HJ, Offer M, Millar DJ, Petrie A, Hawkins PN et al.. (2010) Sustained pharmacological depletion of serum amyloid P component in patients with systemic amyloidosis. Br. J. Haematol., 148 (5): 760-7. [PMID:20064157]
5. Kolstoe SE, Wood SP. (2010) Drug targets for amyloidosis. Biochem. Soc. Trans., 38 (2): 466-70. [PMID:20298204]
6. Li XA, Yutani C, Shimokado K. (1998) Serum amyloid P component associates with high density lipoprotein as well as very low density lipoprotein but not with low density lipoprotein. Biochem. Biophys. Res. Commun., 244 (1): 249-52. [PMID:9514915]
7. Painter RH, De Escallón I, Massey A, Pinteric L, Stern SB. (1982) The structure and binding characteristics of serum amyloid protein (9.5S alpha 1-glycoprotein). Ann. N. Y. Acad. Sci., 389: 199-215. [PMID:6807178]
8. Pepys MB, Dash AC. (1977) Isolation of amyloid P component (protein AP) from normal serum as a calcium-dependent binding protein. Lancet, 1 (8020): 1029-31. [PMID:67487]
9. Pepys MB, Dash AC, Fletcher TC, Richardson N, Munn EA, Feinstein A. (1978) Analogues in other mammals and in fish of human plasma proteins, C-reactive protein and amyloid P component. Nature, 273 (5658): 168-70. [PMID:417269]
10. Pepys MB, Dyck RF, de Beer FC, Skinner M, Cohen AS. (1979) Binding of serum amyloid P-component (SAP) by amyloid fibrils. Clin. Exp. Immunol., 38 (2): 284-93. [PMID:118839]
11. Skinner M, Vaitukaitis JL, Cohen AS, Benson MD. (1979) Serum amyloid P-component levels in amyloidosis, connective tissue diseases, infection, and malignancy as compared to normal serum. J. Lab. Clin. Med., 94 (4): 633-8. [PMID:479670]
12. Wang M, Jin W, Guo AM, Stubbe J. (2013) Cardiovascular inflammation. Mediators Inflamm., 2013: 123513. [PMID:23983400]
13. Wermuth CG. (2004) Selective optimization of side activities: another way for drug discovery. J. Med. Chem., 47 (6): 1303-14. [PMID:14998318]
14. Westermark P, Shirahama T, Skinner M, Norén P, Cohen AS. (1981) Amyloid P-component (protein AP) in localized amyloidosis as revealed by an immunocytochemical method. Histochemistry, 71 (2): 171-5. [PMID:7016817]
Database page citation:
Serum pentaxins. Accessed on 29/04/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=907.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Buneman OP, Catterall WA, Cidlowski JA, Davenport AP, Fabbro D, Fan G, McGrath JC, Spedding M, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Overview. Br J Pharmacol. 172: 5729-5743.