Nucleoside synthesis and metabolism C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

GtoImmuPdb view: OFF   

Overview

« Hide

The de novo synthesis and salvage of nucleosides have been targetted for therapeutic advantage in the treatment of particular cancers and gout. Dihydrofolate reductase produces tetrahydrofolate, a cofactor required for synthesis of purines, pyrimidines and amino acids. GART allows formylation of phosphoribosylglycinamide, an early step in purine biosynthesis. Dihydroorotate dehydrogenase produces orotate, a key intermediate in pyrimidine synthesis. IMP dehydrogenase generates xanthosine monophosphate, an intermediate in GTP synthesis.

Enzymes

dihydrofolate reductase C Show summary » More detailed page

dihydroorotate dehydrogenase (quinone) C Show summary » More detailed page

inosine monophosphate dehydrogenase 1 C Show summary » More detailed page

inosine monophosphate dehydrogenase 2 C Show summary » More detailed page

xanthine dehydrogenase C Show summary » More detailed page

ribonucleotide reductase catalytic subunit M1 C Show summary » More detailed page

ribonucleotide reductase regulatory subunit M2 C Show summary » More detailed page

ribonucleotide reductase regulatory TP53 inducible subunit M2B C Show summary » More detailed page

thymidylate synthetase C Show summary » More detailed page

GART (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase) C Show summary » More detailed page

purine nucleoside phosphorylase C Show summary » More detailed page

Comments

Show »

Further reading

Show »

References

Show »

How to cite this family page

Database page citation:

Nucleoside synthesis and metabolism. Accessed on 27/05/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=920.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.