1.1.1.42 Isocitrate dehydrogenases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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Isocitrate dehydrogenase (IDH) enzymes are crucial components of the central cellular metabolic pathway, the Krebs cycle. The enzymes catalyze the oxidative decarboxylation of isocitrate to produce α-ketoglutarate and carbon dioxide.

Enzymes

isocitrate dehydrogenase (NADP(+)) 1, cytosolic / IDH1 C Show summary » More detailed page

isocitrate dehydrogenase (NADP(+)) 2, mitochondrial / IDH2 C Show summary » More detailed page

References

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How to cite this family page

Database page citation:

1.1.1.42 Isocitrate dehydrogenases. Accessed on 14/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=922.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.