Nitric oxide (NO)-sensitive (soluble) guanylyl cyclase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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Nitric oxide (NO)-sensitive (soluble) guanylyl cyclase (GTP diphosphate-lyase (cyclising)), E.C. 4.6.1.2, is a heterodimer comprising a β1 subunit and one of two alpha subunits (α1, α2) giving rise to two functionally indistinguishable isoforms, GC-1 (α1β1) and GC-2 (α2β1) [8,12]. A haem group is associated with the β subunit and is the target for the endogenous ligand NO, and, potentially, carbon monoxide [3]. The enzyme converts guanosine-5'-triphosphate to the intracellular second messenger cyclic guanosine-3',5'-monophosphate (cyclic GMP).

Enzymes

Complexes

GC-1 (Guanylyl cyclase, α1β1) C Show summary » More detailed page

GC-2 (Guanylyl cyclase, α2β1) C Show summary » More detailed page

Enzymes and Subunits

Guanylyl cyclase α1 subunit C Show summary »

Guanylyl cyclase α2 subunit C Show summary »

Guanylyl cyclase β1 subunit C Show summary »

Guanylyl cyclase β2 subunit C Show summary »

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation:

Adrian Hobbs, Scott Waldman, Annie Beuve, Peter Brouckaert, John C. Burnett, Andreas Friebe, John Garthwaite, Doris Koesling, Michaela Kuhn, Lincoln Potter, Harald Schmidt. Nitric oxide (NO)-sensitive (soluble) guanylyl cyclase. Accessed on 28/05/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=939.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.