RIG-I-like receptor family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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There are three human RIG-I-like receptors (RLRs) which are cytoplasmic pattern recognition receptors (PRRs) of the innate immune system. They detect non-self cytosolic double-stranded RNA species from various sources and are essential for inducing production of the type I interferon, IFNβ, and other anti-pathogenic effectors [1-2].


RIG-1 (DExD/H-box helicase 58) Show summary » More detailed page

MDA5 (interferon induced with helicase C domain 1) Show summary » More detailed page

LGP2 (DExH-box helicase 58) Show summary » More detailed page


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How to cite this family page

Database page citation:

RIG-I-like receptor family. Accessed on 21/11/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=940.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors. Br J Pharmacol. 172: 5979-6023.