Other immune checkpoint proteins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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Checkpoint proteins include co-inhibitory and co-stimulatory receptors on immune effectors cells. Blocking monoclonal antibodies (mAbs) to co-inhibitory receptors such as PD-1 and CTLA4 have sucessfully entered clinical practice as cancer immunotherapies. Co-stimulatory receptors such as GITR, ICOS and OX40 are being targeted by immunostimulatory mAbs in preclinical and clinical development programmes [3].

Targets

CD86 C Show summary » More detailed page

CD80 C Show summary » More detailed page

CD28 Show summary » More detailed page

ILDR2 (immunoglobulin like domain containing receptor 2) Show summary » More detailed page

LAG3 (CD223) / CD223 Show summary » More detailed page

CTLA-4 (cytotoxic T-lymphocyte-associated protein 4 (CD152)) C Show summary » More detailed page

PD-1 (programmed cell death 1 (CD279)) C Show summary » More detailed page

B7-H3 (CD276) Show summary » More detailed page

ICOS (CD278) Show summary » More detailed page

SIGLEC-2 (CD22) Show summary » More detailed page

SIGLEC-3 (CD33) C Show summary » More detailed page

TIM3 (CD366) Show summary » More detailed page

TIGIT Show summary » More detailed page

V-set immunoregulatory receptor Show summary » More detailed page

References

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How to cite this family page

Database page citation:

Other immune checkpoint proteins. Accessed on 23/06/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=949.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Overview. Br J Pharmacol. 174 Suppl 1: S1-S16.