NADPH oxidases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

GtoImmuPdb view: OFF   

Overview

« Hide More detailed introduction

The two DUOX enzymes were originally identified as participating in the production of hydrogen peroxide as a pre-requisite for thyroid hormone biosynthesis in the thyroid gland [1].
NOX enzymes function to catalyse the reduction of molecular oxygen to superoxide and various other reactive oxygen species (ROS). They are subunits of the NADPH oxidase complex.

Enzymes

DUOX1 (dual oxidase 1) Show summary » More detailed page

DUOX2 (dual oxidase 2) Show summary » More detailed page

NOX1 (NADPH oxidase 1) Show summary » More detailed page

NOX2 (cytochrome b-245 beta chain) Show summary » More detailed page

NOX3 (NADPH oxidase 3) Show summary » More detailed page

NOX4 (NADPH oxidase 4) Show summary » More detailed page

NOX5 (NADPH oxidase 5) Show summary » More detailed page

References

Show »

How to cite this family page

Database page citation:

NADPH oxidases. Accessed on 26/09/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=993.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.