G protein-coupled receptors

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5-Hydroxytryptamine receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
5-Hydroxytryptamine receptors 5-hydroxytryptamine
5-HT1A receptor HTR1A
Htr1a
Htr1a
5-Hydroxytryptamine receptors 5-hydroxytryptamine
5-HT1B receptor HTR1B
Htr1b
Htr1b
Endogenous ligand tryptamine is a weak agonist
5-Hydroxytryptamine receptors 5-hydroxytryptamine
5-HT1D receptor HTR1D
Htr1d
Htr1d
5-Hydroxytryptamine receptors 5-hydroxytryptamine
5-ht1e receptor HTR1E
Endogenous ligand tryptamine is a weak agonist
5-Hydroxytryptamine receptors 5-hydroxytryptamine
5-HT1F receptor HTR1F
Htr1f
Htr1f
5-Hydroxytryptamine receptors 5-hydroxytryptamine
5-HT2A receptor HTR2A
Htr2a
Htr2a
5-Hydroxytryptamine receptors 5-hydroxytryptamine
5-HT2B receptor HTR2B
Htr2b
Htr2b
5-Hydroxytryptamine receptors 5-hydroxytryptamine
5-HT2C receptor HTR2C
Htr2c
Htr2c
5-Hydroxytryptamine receptors 5-hydroxytryptamine
5-HT4 receptor HTR4
Htr4
Htr4
5-Hydroxytryptamine receptors 5-hydroxytryptamine
5-ht5a receptor HTR5A
Htr5a
Htr5a
5-Hydroxytryptamine receptors 5-hydroxytryptamine
5-ht5b receptor HTR5BP
Htr5b
Htr5b
5-Hydroxytryptamine receptors 5-hydroxytryptamine
5-HT6 receptor HTR6
Htr6
Htr6
5-Hydroxytryptamine receptors 5-hydroxytryptamine
5-HT7 receptor HTR7
Htr7
Htr7
Acetylcholine receptors (muscarinic)
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Acetylcholine receptors (muscarinic) acetylcholine
M1 receptor CHRM1
Chrm1
Chrm1
Acetylcholine receptors (muscarinic) acetylcholine
M2 receptor CHRM2
Chrm2
Chrm2
Acetylcholine receptors (muscarinic) acetylcholine
M3 receptor CHRM3
Chrm3
Chrm3
Acetylcholine receptors (muscarinic) acetylcholine
M4 receptor CHRM4
Chrm4
Chrm4
Acetylcholine receptors (muscarinic) acetylcholine
M5 receptor CHRM5
Chrm5
Chrm5
Adenosine receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Adenosine receptors adenosine
A1 receptor ADORA1
Adora1
Adora1
Adenosine receptors adenosine
A2A receptor ADORA2A
Adora2a
Adora2a
Adenosine receptors adenosine
A2B receptor ADORA2B
Adora2b
Adora2b
Adenosine receptors adenosine
A3 receptor ADORA3
Adora3
Adora3
Adrenoceptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Adrenoceptors (-)-adrenaline
(-)-noradrenaline
α1A-adrenoceptor ADRA1A
Adra1a
Adra1a
Adrenoceptors (-)-adrenaline
(-)-noradrenaline
α1B-adrenoceptor ADRA1B
Adra1b
Adra1b
Adrenoceptors (-)-adrenaline
(-)-noradrenaline
α1D-adrenoceptor ADRA1D
Adra1d
Adra1d
Adrenoceptors (-)-adrenaline
(-)-noradrenaline
α2A-adrenoceptor ADRA2A
Adra2a
Adra2a
Adrenaline exhibits greater relative potency than noradrenaline
Adrenoceptors (-)-adrenaline
(-)-noradrenaline
α2B-adrenoceptor ADRA2B
Adra2b
Adra2b
Adrenaline exhibits greater relative potency than noradrenaline
Adrenoceptors (-)-adrenaline
(-)-noradrenaline
α2C-adrenoceptor ADRA2C
Adra2c
Adra2c
Adrenaline exhibits greater relative potency than noradrenaline
Adrenoceptors (-)-adrenaline
(-)-noradrenaline
β1-adrenoceptor ADRB1
Adrb1
Adrb1
Noradrenaline exhibits greater potency than adrenaline
Adrenoceptors (-)-adrenaline
(-)-noradrenaline
β2-adrenoceptor ADRB2
Adrb2
Adrb2
Adrenaline exhibits greater potency than noradrenaline
Adrenoceptors (-)-adrenaline
(-)-noradrenaline
β3-adrenoceptor ADRB3
Adrb3
Adrb3
Angiotensin receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Angiotensin receptors angiotensin II {Sp: Human, Mouse, Rat}
angiotensin III {Sp: Human, Mouse, Rat}
AT1 receptor AGTR1
Agtr1a
Agtr1b
Agtr1b
Agtr1a
Angiotensin receptors angiotensin II {Sp: Human, Mouse, Rat}
angiotensin III {Sp: Human, Mouse, Rat}
AT2 receptor AGTR2
Agtr2
Agtr2
Apelin receptor
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Apelin receptor apelin-36 {Sp: Human}
apelin-13 {Sp: Human, Mouse, Rat}
apelin-17 {Sp: Human, Mouse, Rat}
apelin-36 {Sp: Mouse, Rat}
apelin receptor early endogenous ligand {Sp: Human} , apelin receptor early endogenous ligand {Sp: Mouse}
[Pyr1]apelin-13 {Sp: Human, Mouse, Rat}
apelin receptor APLNR
Aplnr
Aplnr
Bile acid receptor
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Bile acid receptor chenodeoxycholic acid
cholic acid
deoxycholic acid
lithocholic acid
GPBA receptor GPBAR1
Gpbar1
Gpbar1
Bombesin receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Bombesin receptors gastrin-releasing peptide {Sp: Human} , gastrin-releasing peptide {Sp: Mouse, Rat} , gastrin-releasing peptide {Sp: Pig}
GRP-(18-27) {Sp: Human, Pig} , GRP-(18-27) {Sp: Mouse, Rat}
neuromedin B {Sp: Human, Mouse, Rat, Pig}
BB1 receptor NMBR
Nmbr
Nmbr
Neuromedin B is the endogenous agonist with the greatest potency
Bombesin receptors gastrin-releasing peptide {Sp: Human} , gastrin-releasing peptide {Sp: Mouse, Rat} , gastrin-releasing peptide {Sp: Pig}
GRP-(18-27) {Sp: Human, Pig} , GRP-(18-27) {Sp: Mouse, Rat}
neuromedin B {Sp: Human, Mouse, Rat, Pig}
BB2 receptor GRPR
Grpr
Grpr
Gastrin-releasing peptide is the endogenous agonist with the greatest potency
Bombesin receptors BB3 receptor BRS3
Brs3
Brs3
Bradykinin receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Bradykinin receptors bradykinin {Sp: Human, Mouse, Rat}
[des-Arg9]bradykinin {Sp: Human, Mouse, Rat}
[des-Arg10]kallidin {Sp: Human}
[Hyp3]bradykinin {Sp: Human}
kallidin {Sp: Human}
Lys-[Hyp3]-bradykinin {Sp: Human, Mouse, Rat}
T-kinin {Sp: Human, Rat}
B1 receptor BDKRB1
Bdkrb1
Bdkrb1
[Des-Arg10]kallidin is the most potent endogenous ligand
Bradykinin receptors bradykinin {Sp: Human, Mouse, Rat}
[des-Arg9]bradykinin {Sp: Human, Mouse, Rat}
[des-Arg10]kallidin {Sp: Human}
[Hyp3]bradykinin {Sp: Human}
kallidin {Sp: Human}
Lys-[Hyp3]-bradykinin {Sp: Human, Mouse, Rat}
T-kinin {Sp: Human, Rat}
B2 receptor BDKRB2
Bdkrb2
Bdkrb2
Bradykinin and kallidin are the most potent endogenous ligands
Cannabinoid receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Cannabinoid receptors anandamide
2-arachidonoylglycerol
CB1 receptor CNR1
Cnr1
Cnr1
Endogenous ligands include other endocannabinoids
Cannabinoid receptors anandamide
2-arachidonoylglycerol
CB2 receptor CNR2
Cnr2
Cnr2
Endogenous ligands include other endocannabinoids
Chemerin receptor
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Chemerin receptor chemerin {Sp: Human}
resolvin E1
chemerin receptor CMKLR1
Cmklr1
Cmklr1
Chemokine receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Chemokine receptors CCL14 {Sp: Human}
CCL15 {Sp: Human}
CCL23 {Sp: Human}
CCL3 {Sp: Human}
CCL5 {Sp: Human}
CCL7 {Sp: Human}
CCL13 {Sp: Human}
CCL8 {Sp: Human}
CCL16 {Sp: Human}
CCL4 {Sp: Human}
CCL3 {Sp: Mouse}
CCL7 {Sp: Mouse}
CCL8 {Sp: Mouse}
CCL4 {Sp: Mouse}
CCL5 {Sp: Mouse, Rat}
CCL3 {Sp: Rat}
CCL7 {Sp: Rat}
CCL4 {Sp: Rat}
CCR1 CCR1
Ccr1
Ccr1
CCL15 and CCL23 are the principal endogenous agonists
Chemokine receptors CCL7 {Sp: Human}
CCL13 {Sp: Human}
CCL2 {Sp: Human}
CCL8 {Sp: Human}
CCL16 {Sp: Human}
CCL11 {Sp: Human}
CCL26 {Sp: Human}
CCL2 {Sp: Mouse}
CCL7 {Sp: Mouse}
CCL8 {Sp: Mouse}
CCL11 {Sp: Mouse}
CCL2 {Sp: Rat}
CCL7 {Sp: Rat}
CCL11 {Sp: Rat}
CCR2 CCR2
Ccr2
Ccr2
CCL2 is the principal endogenous agonist
Chemokine receptors CCL15 {Sp: Human}
CCL5 {Sp: Human}
CCL7 {Sp: Human}
CCL11 {Sp: Human}
CCL13 {Sp: Human}
CCL8 {Sp: Human}
CCL24 {Sp: Human}
CCL26 {Sp: Human}
CCL2 {Sp: Human}
CCL28 {Sp: Human}
CCL11 {Sp: Mouse}
CCL7 {Sp: Mouse}
CCL8 {Sp: Mouse}
CCL24 {Sp: Mouse}
CCL2 {Sp: Mouse}
CCL28 {Sp: Mouse}
CCL5 {Sp: Mouse, Rat}
CCL7 {Sp: Rat}
CCL11 {Sp: Rat}
CCL2 {Sp: Rat}
CXCL9 {Sp: Human}
CXCL10 {Sp: Human}
CXCL11 {Sp: Human}
CXCL9 {Sp: Mouse}
CXCL10 {Sp: Mouse}
CXCL11 {Sp: Mouse}
CXCL10 {Sp: Rat}
CCR3 CCR3
Ccr3
Ccr3
CCL11, CCL24 and CCL26 are the principal endogenous agonists
Chemokine receptors CCL17 {Sp: Human}
CCL22 {Sp: Human} , CCL22 {Sp: Mouse}
CCR4 CCR4
Ccr4
Ccr4
Chemokine receptors CCL14 {Sp: Human}
CCL3 {Sp: Human}
CCL4 {Sp: Human}
CCL5 {Sp: Human}
CCL11 {Sp: Human}
CCL8 {Sp: Human}
CCL16 {Sp: Human}
CCL2 {Sp: Human}
CCL7 {Sp: Human}
CCL11 {Sp: Mouse}
CCL3 {Sp: Mouse}
CCL4 {Sp: Mouse}
CCL8 {Sp: Mouse}
CCL2 {Sp: Mouse}
CCL7 {Sp: Mouse}
CCL5 {Sp: Mouse, Rat}
CCL3 {Sp: Rat}
CCL4 {Sp: Rat}
CCL11 {Sp: Rat}
CCL2 {Sp: Rat}
CCL7 {Sp: Rat}
CCR5 CCR5
Ccr5
Ccr5
Chemokine receptors beta-defensin 4A {Sp: Human}
CCL20 {Sp: Human} , CCL20 {Sp: Mouse} , CCL20 {Sp: Rat}
CCR6 CCR6
Ccr6
Ccr6
Chemokine receptors CCL19 {Sp: Human}
CCL21 {Sp: Human}
CCL19 {Sp: Mouse}
CCR7 CCR7
Ccr7
Ccr7
Chemokine receptors CCL1 {Sp: Human} , CCL1 {Sp: Mouse}
CCL8 {Sp: Mouse}
CCR8 CCR8
Ccr8
Ccr8
CCL1 is the principal endogenous agonist
Chemokine receptors CCL25 {Sp: Human} , CCL25 {Sp: Mouse}
CCR9 CCR9
Ccr9
Ccr9
Chemokine receptors CCL27 {Sp: Human}
CCL28 {Sp: Human}
CCL27 {Sp: Mouse}
CCL28 {Sp: Mouse}
CCR10 CCR10
Ccr10
Ccr10
Chemokine receptors CXCL6 {Sp: Human}
CXCL8 {Sp: Human}
CXCL1 {Sp: Human} , CXCL1 {Sp: Mouse} , CXCL1 {Sp: Rat}
CXCR1 CXCR1
Cxcr1
Cxcr1
CXCL8 is the principal endogenous agonist
Chemokine receptors CXCL1 {Sp: Human}
CXCL6 {Sp: Human}
CXCL8 {Sp: Human}
CXCL2 {Sp: Human}
CXCL3 {Sp: Human}
CXCL5 {Sp: Human}
CXCL7 {Sp: Human}
CXCL1 {Sp: Mouse}
CXCL2 {Sp: Mouse}
CXCL3 {Sp: Mouse}
CXCL5 {Sp: Mouse}
CXCL1 {Sp: Rat}
CXCL2 {Sp: Rat}
CXCL3 {Sp: Rat}
CXCL5 {Sp: Rat}
CXCR2 CXCR2
Cxcr2
Cxcr2
macrophage derived lectin is a proposed ligand, single publication
Chemokine receptors CXCL10 {Sp: Human}
CXCL11 {Sp: Human}
CXCL9 {Sp: Human} , CXCL9 {Sp: Mouse}
CXCL10 {Sp: Mouse}
CXCL11 {Sp: Mouse}
CXCL10 {Sp: Rat}
CXCR3 CXCR3
Cxcr3
Cxcr3
Chemokine receptors CXCL12β {Sp: Human}
CXCL12α {Sp: Human}
CXCL12 {Sp: Mouse}
CXCR4 CXCR4
Cxcr4
Cxcr4
SDF1α and SDF1β are the active isomers of CXCL12
Chemokine receptors CXCL13 {Sp: Human} , CXCL13 {Sp: Mouse}
CXCR5 CXCR5
Cxcr5
Cxcr5
Chemokine receptors CXCL16 {Sp: Human} , CXCL16 {Sp: Mouse} , CXCL16 {Sp: Rat}
CXCR6 CXCR6
Cxcr6
Cxcr6
Chemokine receptors CX3CL1 {Sp: Human} , CX3CL1 {Sp: Mouse} , CX3CL1 {Sp: Rat}
CX3CR1 CX3CR1
Cx3cr1
Cx3cr1
Chemokine receptors XCL1 {Sp: Human}
XCL2 {Sp: Human}
XCL1 {Sp: Mouse} , XCL1 {Sp: Rat}
XCR1 XCR1
Xcr1
Xcr1
Chemokine receptors ACKR1 ACKR1
Ackr1
Ackr1
Chemokine receptors ACKR2 ACKR2
Ackr2
Ackr2
Chemokine receptors CXCL11 {Sp: Human}
CXCL12α {Sp: Human}
ACKR3 ACKR3
Ackr3
Ackr3
Several lines of evidence have suggested that adrenomedullin is a ligand for ACKR3; however, classical direct binding to the receptor has not yet been convincingly demonstrated.
Chemokine receptors ACKR4 ACKR4
Ackr4
Ackr4
Chemokine receptors CCL19 {Sp: Human} , CCL19 {Sp: Mouse}
CCRL2 CCRL2
Ccrl2
Ccrl2
Cholecystokinin receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Cholecystokinin receptors CCK-4 {Sp: Human}
CCK-33 {Sp: Human}
CCK-8 {Sp: Human, Mouse, Rat}
CCK-33 {Sp: Mouse} , CCK-33 {Sp: Rat}
gastrin-17 {Sp: Human} , gastrin-17 {Sp: Mouse} , gastrin-17 {Sp: Rat}
CCK1 receptor CCKAR
Cckar
Cckar
CCK-58 is an endogenous peptide fragment from the cholecystokinin precursor protein, but there is no affinity data available for this ligand at cholecystokinin receptors. For the rodent homologues of this peptide please see the following ligand entries: CCK-58 (mouse) and CCK-58 (rat).
Cholecystokinin receptors CCK-4 {Sp: Human}
CCK-33 {Sp: Human}
CCK-8 {Sp: Human, Mouse, Rat}
CCK-33 {Sp: Mouse} , CCK-33 {Sp: Rat}
gastrin-17 {Sp: Human} , gastrin-17 {Sp: Mouse} , gastrin-17 {Sp: Rat}
CCK2 receptor CCKBR
Cckbr
Cckbr
CCK-58 is an endogenous peptide fragment from the cholecystokinin precursor protein, but there is no affinity data available for this ligand at cholecystokinin receptors. For the rodent homologues of this peptide please see the following ligand entries: CCK-58 (mouse) and CCK-58 (rat). Gastrin-34 is one of the main forms of secreted gastrin present in the blood but there is no activity data for its interactions with this receptor. For the rodent homologues of this peptide please see gastrin-34 (mouse) and gastrin-34 (rat). Desulfated gastrin-14 (minigastrin) is an endogenous antagonist of cholecystokinin and radiolabelled analogues of this peptide are used as probes for this receptor. The gastrin precursor peptide is also cleaved into larger peptides gastrin-52 and gastrin-71.
Class A Orphans
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Class A Orphans GPR1 GPR1
Gpr1
Gpr1
Class A Orphans BB3 receptor BRS3
Brs3
Brs3
Class A Orphans sphingosine 1-phosphate
GPR3 GPR3
Gpr3
Gpr3
Proposed ligand, single publication
Class A Orphans Protons GPR4 GPR4
Gpr4
Gpr4
The role of GPR4 as a proton-sensing receptor is supported by several publications.
Class A Orphans GPR42 GPR42
Very closely related to GPR41. Might be a pseudogene.
Class A Orphans sphingosine 1-phosphate
GPR6 GPR6
Gpr6
Gpr6
Proposed ligand, single publication
Class A Orphans sphingosine 1-phosphate
GPR12 GPR12
Gpr12
Gpr12
Proposed ligand, single publication
Class A Orphans GPR15 GPR15
Gpr15
Gpr15
Class A Orphans cysteinyl-leukotrienes (CysLTs), uracil nucleotides GPR17 GPR17
Gpr17
Gpr17
Proposed ligands, single publication
Class A Orphans N-arachidonoylglycine
GPR18 GPR18
Gpr18
Gpr18
Class A Orphans GPR19 GPR19
Gpr19
Gpr19
Class A Orphans GPR20 GPR20
Gpr20
Gpr20
Class A Orphans GPR21 GPR21
Gpr21
Gpr21
Class A Orphans GPR22 GPR22
Gpr22
Gpr22
Class A Orphans GPR25 GPR25
Gpr25
Gpr25
Class A Orphans GPR26 GPR26
Gpr26
Gpr26
Class A Orphans GPR27 GPR27
Gpr27
Gpr27
Class A Orphans GPR31 GPR31
Gpr31
Gpr31c
Proposed ligand, single publication
Class A Orphans resolvin D1
GPR32 GPR32
Proposed ligand, single publication
Class A Orphans GPR33 GPR33
Gpr33
Gpr33
pseudogene in most individuals
Class A Orphans lysophosphatidylserine
GPR34 GPR34
Gpr34
Gpr34
Proposed ligand in several publications but not replicated in a recent study based on β-arrestin recruitment [...].
Class A Orphans kynurenic acid
2-oleoyl-LPA
GPR35 GPR35
Gpr35
Gpr35
Proposed ligands, single publications
Class A Orphans prosaposin GPR37 GPR37
Gpr37
Gpr37
Proposed ligand, single publication
Class A Orphans prosaposin GPR37L1 GPR37L1
Gpr37l1
Gpr37l1
Proposed ligand, single publication.
Class A Orphans obestatin {Sp: Human} , obestatin {Sp: Mouse, Rat}
Zn2+
GPR39 GPR39
Gpr39
Gpr39
Proposed ligands, single publications, but results for obestatin could not be repeated and have since been retracted
Class A Orphans GPR45 GPR45
Gpr45
Gpr45
Class A Orphans GPR50 GPR50
Gpr50
Gpr50
Class A Orphans GPR52 GPR52
Gpr52
Gpr52
Class A Orphans lysophosphatidylinositol
GPR55 GPR55
Gpr55
Gpr55
Proposed ligand, several publications
Class A Orphans GPR61 GPR61
Gpr61
Gpr61
Class A Orphans GPR62 GPR62
Gpr62
Gpr62
Class A Orphans dihydrosphingosine-1-phosphate
dioleoylphosphatidic acid
sphingosine 1-phosphate
GPR63 GPR63
Gpr63
Gpr63
Proposed ligand, single publication
Class A Orphans Protons GPR65 GPR65
Gpr65
Gpr65
Class A Orphans Protons GPR68 GPR68
Gpr68
Gpr68
Class A Orphans CCL5 {Sp: Human}
GPR75 GPR75
Gpr75
Gpr75
CCL5 was reported to be an agonist of GPR75 by Ignatov et al. [...] but the pairing could not be repeated in a recent β-arrestin assay [...].
Class A Orphans GPR78 GPR78
Class A Orphans GPR79 GPR79
Class A Orphans GPR82 GPR82
Gpr82
Class A Orphans GPR83 GPR83
Gpr83
Gpr83
Class A Orphans Medium-chain-length fatty acids GPR84 GPR84
Gpr84
Gpr84
Medium chain free fatty acids with carbon chain lengths of 9-14 have been shown by several groups to activate GPR84 [...][...][...]. A surrogate ligand for GPR84, 6-n-octylaminouracil, has also been proposed [...].
Class A Orphans GPR85 GPR85
Gpr85
Gpr85
Class A Orphans LPA
GPR87 GPR87
Gpr87
Gpr87
Proposed ligand, single publication
Class A Orphans GPR88 GPR88
Gpr88
Gpr88
Class A Orphans GPR101 GPR101
Gpr101
Gpr101
Class A Orphans N-oleoylethanolamide
GPR119 GPR119
Gpr119
Gpr119
Proposed ligand, two publications
Class A Orphans (lyso)phospholipid mediators, protons GPR132 GPR132
Gpr132
Gpr132
Class A Orphans GPR135 GPR135
Gpr135
Gpr135
Class A Orphans GPR139 GPR139
Gpr139
Gpr139
Class A Orphans GPR141 GPR141
Gpr141
Gpr141
Class A Orphans GPR142 GPR142
Gpr142
Gpr142
Class A Orphans GPR146 GPR146
Gpr146
Gpr146
Class A Orphans GPR148 GPR148
Class A Orphans GPR149 GPR149
Gpr149
Gpr149
Class A Orphans GPR150 GPR150
Gpr150
Gpr150
Class A Orphans GPR151 GPR151
Gpr151
Gpr151
Class A Orphans GPR152 GPR152
Gpr152
Gpr152
Class A Orphans GPR153 GPR153
Gpr153
Gpr153
Class A Orphans GPR160 GPR160
Gpr160
Gpr160
Class A Orphans GPR161 GPR161
Gpr161
Gpr161
Class A Orphans GPR162 GPR162
Gpr162
Gpr162
Class A Orphans GPR171 GPR171
Gpr171
Gpr171
Class A Orphans GPR173 GPR173
Gpr173
Gpr173
Class A Orphans lysophosphatidylserine
GPR174 GPR174
Gpr174
Gpr174
Proposed ligand, two publications
Class A Orphans GPR176 GPR176
Gpr176
Gpr176
Class A Orphans GPR182 GPR182
Gpr182
Gpr182
Class A Orphans 7α,25-dihydroxycholesterol
Oxysterols
GPR183 GPR183
Gpr183
Gpr183
Proposed ligands, two independent publications
Class A Orphans R-spondins LGR4 LGR4
Lgr4
Lgr4
Proposed ligands, single publication
Class A Orphans LGR5 LGR5
Lgr5
Lgr5
Class A Orphans R-spondins LGR6 LGR6
Lgr6
Lgr6
Proposed ligands, single publication
Class A Orphans MAS1 MAS1
Mas1
Mas1
Class A Orphans MAS1L MAS1L
Class A Orphans β-alanine
MRGPRD MRGPRD
Mrgprd
Mrgprd
Proposed ligand, two publications
Class A Orphans MRGPRE MRGPRE
Mrgpre
Mrgpre
Class A Orphans MRGPRF MRGPRF
Mrgprf
Mrgprf
Class A Orphans MRGPRG MRGPRG
Mrgprg
Mrgprg
Class A Orphans bovine adrenal medulla peptide 8-22 {Sp: Human}
MRGPRX1 MRGPRX1
Proposed ligand, two publications
Class A Orphans cortistatin-14 {Sp: Mouse, Rat}
MRGPRX2 MRGPRX2
Proposed ligand, two publications
Class A Orphans MRGPRX3 MRGPRX3
Class A Orphans MRGPRX4 MRGPRX4
Class A Orphans OPN3 OPN3
Opn3
Opn3
Probably a sensory receptor.
Class A Orphans OPN4 OPN4
Opn4
Opn4
Class A Orphans OPN5 OPN5
Opn5
Opn5
Class A Orphans P2RY8 P2RY8
Class A Orphans LPA
sphingosine 1-phosphate
P2RY10 P2RY10
P2ry10
P2ry10
Proposed ligands, single publication
Class A Orphans TAAR2 TAAR2
Taar2
Taar2
Class A Orphans TAAR3 TAAR3
Taar3
Taar3
probable pseudogene.
Class A Orphans TAAR4P TAAR4P
Taar4
Taar4
Class A Orphans TAAR5 TAAR5
Taar5
Taar5
Class A Orphans TAAR6 TAAR6
Taar6
Taar6
Class A Orphans TAAR8 TAAR8
Taar8a
Taar8a
Class A Orphans TAAR9 TAAR9
Taar9
Taar9
Complement peptide receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Complement peptide receptors C5a {Sp: Human}
C3a {Sp: Human}
C5a {Sp: Mouse}
C3a {Sp: Mouse}
C5a {Sp: Rat}
C3a {Sp: Rat}
C3a receptor C3AR1
C3ar1
C3ar1
C3a anaphylatoxin has a higher potency than C5a anaphylatoxin
Complement peptide receptors C5a {Sp: Human}
C3a {Sp: Human}
C5a {Sp: Mouse}
C3a {Sp: Mouse}
C5a {Sp: Rat}
C3a {Sp: Rat}
C5a1 receptor C5AR1
C5ar1
C5ar1
C5a anaphylatoxin has a higher potency than C3a anaphylatoxin
Complement peptide receptors C5a2 receptor C5AR2
C5ar2
C5ar2
Dopamine receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Dopamine receptors dopamine
D1 receptor DRD1
Drd1
Drd1
Dopamine receptors dopamine
D2 receptor DRD2
Drd2
Drd2
Dopamine receptors dopamine
D3 receptor DRD3
Drd3
Drd3
Dopamine receptors dopamine
D4 receptor DRD4
Drd4
Drd4
Dopamine receptors dopamine
D5 receptor DRD5
Drd5
Drd5
Endothelin receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Endothelin receptors endothelin-2 {Sp: Human}
endothelin-1 {Sp: Human, Mouse, Rat}
endothelin-2 {Sp: Mouse, Rat}
ETA receptor EDNRA
Ednra
Ednra
Endothelin-3 is a low potency endogenous agonist
Endothelin receptors endothelin-2 {Sp: Human}
endothelin-1 {Sp: Human, Mouse, Rat}
endothelin-3 {Sp: Human, Mouse, Rat}
endothelin-2 {Sp: Mouse, Rat}
ETB receptor EDNRB
Ednrb
Ednrb
Formylpeptide receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Formylpeptide receptors annexin I {Sp: Human} , annexin I {Sp: Mouse} , annexin I {Sp: Rat}
cathepsin G {Sp: Human} , cathepsin G {Sp: Mouse} , cathepsin G {Sp: Rat}
FPR1 FPR1
Fpr1
Fpr1
Formylpeptide receptors annexin I {Sp: Human} , annexin I {Sp: Mouse} , annexin I {Sp: Rat}
aspirin triggered lipoxin A4
aspirin-triggered resolvin D1
LXA4
resolvin D1
FPR2/ALX FPR2
Fpr2
Fpr2
Formylpeptide receptors F2L {Sp: Human} , F2L {Sp: Mouse, Rat}
humanin {Sp: Human}
FPR3 FPR3
Fpr3
Fpr3
Free fatty acid receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Free fatty acid receptors long chain carboxylic acids FFA1 receptor FFAR1
Ffar1
Ffar1
Free fatty acid receptors FFA2 receptor FFAR2
Ffar2
Ffar2
Free fatty acid receptors FFA3 receptor FFAR3
Ffar3
Ffar3
Free fatty acid receptors Free fatty acids FFA4 receptor FFAR4
Ffar4
Ffar4
Free fatty acid receptors GPR42 GPR42
Very closely related to GPR41. Might be a pseudogene.
Galanin receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Galanin receptors galanin {Sp: Human} , galanin {Sp: Mouse, Rat}
galanin-like peptide {Sp: Human} , galanin-like peptide {Sp: Mouse} , galanin-like peptide {Sp: Rat}
GAL1 receptor GALR1
Galr1
Galr1
Galanin is more potent than galanin-like peptide
Galanin receptors galanin {Sp: Human} , galanin {Sp: Mouse, Rat}
galanin-like peptide {Sp: Human} , galanin-like peptide {Sp: Mouse} , galanin-like peptide {Sp: Rat}
GAL2 receptor GALR2
Galr2
Galr2
Galanin receptors galanin {Sp: Human} , galanin {Sp: Mouse, Rat}
galanin-like peptide {Sp: Human} , galanin-like peptide {Sp: Mouse} , galanin-like peptide {Sp: Rat}
GAL3 receptor GALR3
Galr3
Galr3
Galanin-like peptide is more potent than galanin
Ghrelin receptor
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Ghrelin receptor [des-Gln14]ghrelin {Sp: Human} , [des-Gln14]ghrelin {Sp: Mouse, Rat}
ghrelin {Sp: Human} , ghrelin {Sp: Mouse, Rat}
ghrelin receptor GHSR
Ghsr
Ghsr
The major circulating form of ghrelin is [des-octanoyl]ghrelin (human)/[des-octanoyl]ghrelin (mouse/rat).
Glycoprotein hormone receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Glycoprotein hormone receptors FSH {Sp: Human} , FSH {Sp: Mouse} , FSH {Sp: Rat}
FSH receptor FSHR
Fshr
Fshr
Glycoprotein hormone receptors hCG {Sp: Human}
LH {Sp: Human} , LH {Sp: Mouse} , LH {Sp: Rat}
LH receptor LHCGR
Lhcgr
Lhcgr
Glycoprotein hormone receptors TSH {Sp: Human} , TSH {Sp: Mouse} , TSH {Sp: Rat}
TSH receptor TSHR
Tshr
Tshr
Gonadotrophin-releasing hormone receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Gonadotrophin-releasing hormone receptors GnRH I {Sp: Human, Mouse, Rat}
GnRH II {Sp: Human}
GnRH1 receptor GNRHR
Gnrhr
Gnrhr
GnRH I is the more potent agonist
Gonadotrophin-releasing hormone receptors GnRH I {Sp: Human, Mouse, Rat}
GnRH II {Sp: Human}
GnRH2 receptor GNRHR2
Probable transcribed pseudogene in man [...]. Natural/endogenous ligands refer to non-human mammalian species.
GPR18, GPR55 and GPR119
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
GPR18, GPR55 and GPR119 N-arachidonoylglycine
GPR18 GPR18
Gpr18
Gpr18
GPR18, GPR55 and GPR119 lysophosphatidylinositol
GPR55 GPR55
Gpr55
Gpr55
Proposed ligand, several publications
GPR18, GPR55 and GPR119 N-oleoylethanolamide
GPR119 GPR119
Gpr119
Gpr119
Proposed ligand, two publications
G protein-coupled estrogen receptor
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
G protein-coupled estrogen receptor 17β-estradiol
GPER GPER1
Gper1
Gper1
Proposed ligand in several publications but not replicated in a recent study based on β-arrestin recruitment [...].
Histamine receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Histamine receptors histamine
H1 receptor HRH1
Hrh1
Hrh1
Histamine receptors histamine
H2 receptor HRH2
Hrh2
Hrh2
Histamine receptors histamine
H3 receptor HRH3
Hrh3
Hrh3
Histamine receptors histamine
H4 receptor HRH4
Hrh4
Hrh4
Hydroxycarboxylic acid receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Hydroxycarboxylic acid receptors L-lactic acid
HCA1 receptor HCAR1
Hcar1
Hcar1
Proposed ligand, two publications
Hydroxycarboxylic acid receptors β-D-hydroxybutyric acid
HCA2 receptor HCAR2
Hcar2
Hcar2
Hydroxycarboxylic acid receptors 3-hydroxyoctanoic acid
HCA3 receptor HCAR3
Kisspeptin receptor
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Kisspeptin receptor kisspeptin-10 {Sp: Human}
kisspeptin-13 {Sp: Human}
kisspeptin-14 {Sp: Human}
kisspeptin-54 {Sp: Human}
kisspeptin-52 {Sp: Mouse}
kisspeptin-10 {Sp: Mouse, Rat}
kisspeptin-52 {Sp: Rat}
kisspeptin receptor KISS1R
Kiss1r
Kiss1r
Leukotriene receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Leukotriene receptors 20-hydroxy-LTB4
LTB4
12R-HETE
BLT1 receptor LTB4R
Ltb4r
Ltb4r1
LTB4 is the most potent endogenous agonist
Leukotriene receptors 12-hydroxyheptadecatrienoic acid
20-hydroxy-LTB4
LTB4
12R-HETE
15S-HETE
12S-HETE
12S-HPETE
BLT2 receptor LTB4R2
Ltb4r2
Ltb4r2
12-Hydroxyheptadecatrienoic acid is the most potent endogenous agonist
Leukotriene receptors LTC4
LTD4
LTE4
CysLT1 receptor CYSLTR1
Cysltr1
Cysltr1
LTD4 is the most potent endogenous agonist
Leukotriene receptors LTC4
LTD4
LTE4
CysLT2 receptor CYSLTR2
Cysltr2
Cysltr2
LTC4 and LTD4 are more potent agonists than LTE4
Leukotriene receptors 5-oxo-C20:3
5-oxo-ETE
5-oxo-15-HETE
5-oxo-ODE
5S-HETE
5S-HPETE
OXE receptor OXER1
5-Oxo-ETE and 5-oxo-C20:3 are the most potent endogenous agonists
Leukotriene receptors annexin I {Sp: Human} , annexin I {Sp: Mouse} , annexin I {Sp: Rat}
aspirin triggered lipoxin A4
aspirin-triggered resolvin D1
LXA4
resolvin D1
FPR2/ALX