G protein-coupled receptors

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Calcitonin receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Calcitonin receptors amylin {Sp: Human} , amylin {Sp: Mouse, Rat}
calcitonin {Sp: Human} , calcitonin {Sp: Mouse, Rat}
α-CGRP {Sp: Human}
β-CGRP {Sp: Human} , β-CGRP {Sp: Mouse}
α-CGRP {Sp: Mouse, Rat}
β-CGRP {Sp: Rat}
CT receptor CALCR
Calcr
Calcr
Calcitonin and amylin are the principal endogenous agonists.
Calcitonin receptors adrenomedullin 2/intermedin {Sp: Human} , adrenomedullin 2/intermedin {Sp: Mouse} , adrenomedullin 2/intermedin {Sp: Rat}
amylin {Sp: Human} , amylin {Sp: Mouse, Rat}
calcitonin {Sp: Human} , calcitonin {Sp: Mouse, Rat}
α-CGRP {Sp: Human}
β-CGRP {Sp: Human} , β-CGRP {Sp: Mouse}
α-CGRP {Sp: Mouse, Rat}
β-CGRP {Sp: Rat}
AMY1 receptor Amylin, α-CGRP, and β-CGRP are the most potent endogenous agonists
Calcitonin receptors adrenomedullin 2/intermedin {Sp: Human} , adrenomedullin 2/intermedin {Sp: Mouse} , adrenomedullin 2/intermedin {Sp: Rat}
amylin {Sp: Human} , amylin {Sp: Mouse, Rat}
calcitonin {Sp: Human} , calcitonin {Sp: Mouse, Rat}
α-CGRP {Sp: Human}
β-CGRP {Sp: Human} , β-CGRP {Sp: Mouse}
α-CGRP {Sp: Mouse, Rat}
β-CGRP {Sp: Rat}
AMY2 receptor Amylin is the most potent endogenous agonist
Calcitonin receptors amylin {Sp: Human} , amylin {Sp: Mouse, Rat}
calcitonin {Sp: Human} , calcitonin {Sp: Mouse, Rat}
α-CGRP {Sp: Human}
β-CGRP {Sp: Human} , β-CGRP {Sp: Mouse}
α-CGRP {Sp: Mouse, Rat}
β-CGRP {Sp: Rat}
AMY3 receptor Amylin is the principal endogenous agonist
Calcitonin receptors adrenomedullin, CGRP calcitonin receptor-like receptor CALCRL
Calcrl
Calcrl
Functional receptor is a dimer of 7TM and RAMP; ligand depends on RAMP
Calcitonin receptors adrenomedullin {Sp: Human} , adrenomedullin {Sp: Mouse} , adrenomedullin {Sp: Rat}
adrenomedullin 2/intermedin {Sp: Human} , adrenomedullin 2/intermedin {Sp: Mouse} , adrenomedullin 2/intermedin {Sp: Rat}
α-CGRP {Sp: Human}
β-CGRP {Sp: Human} , β-CGRP {Sp: Mouse}
α-CGRP {Sp: Mouse, Rat}
β-CGRP {Sp: Rat}
CGRP receptor α-CGRP and β-CGRP are the principal endogenous agonists
Calcitonin receptors adrenomedullin {Sp: Human} , adrenomedullin {Sp: Mouse} , adrenomedullin {Sp: Rat}
adrenomedullin 2/intermedin {Sp: Human} , adrenomedullin 2/intermedin {Sp: Mouse} , adrenomedullin 2/intermedin {Sp: Rat}
α-CGRP {Sp: Human}
β-CGRP {Sp: Human} , β-CGRP {Sp: Mouse}
α-CGRP {Sp: Mouse, Rat}
β-CGRP {Sp: Rat}
AM1 receptor Adrenomedullin and adrenomedullin 2/intermedin are the most likely physiological agonists.
Calcitonin receptors adrenomedullin {Sp: Human} , adrenomedullin {Sp: Mouse} , adrenomedullin {Sp: Rat}
adrenomedullin 2/intermedin {Sp: Human} , adrenomedullin 2/intermedin {Sp: Mouse} , adrenomedullin 2/intermedin {Sp: Rat}
α-CGRP {Sp: Human}
β-CGRP {Sp: Human} , β-CGRP {Sp: Mouse}
α-CGRP {Sp: Mouse, Rat}
β-CGRP {Sp: Rat}
AM2 receptor Adrenomedullin and adrenomedullin 2/intermedin are the most potent endogenous agonists
Corticotropin-releasing factor receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Corticotropin-releasing factor receptors corticotrophin-releasing hormone {Sp: Human, Mouse, Rat}
urocortin 1 {Sp: Human} , urocortin 1 {Sp: Mouse, Rat}
CRF1 receptor CRHR1
Crhr1
Crhr1
Corticotropin-releasing factor receptors corticotrophin-releasing hormone {Sp: Human, Mouse, Rat}
urocortin 1 {Sp: Human}
urocortin 2 {Sp: Human}
urocortin 3 {Sp: Human}
urocortin 2 {Sp: Mouse}
urocortin 1 {Sp: Mouse, Rat}
urocortin 3 {Sp: Mouse, Rat}
urocortin 2 {Sp: Rat}
CRF2 receptor CRHR2
Crhr2
Crhr2
Glucagon receptor family
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Glucagon receptor family GHRH {Sp: Human} , GHRH {Sp: Mouse} , GHRH {Sp: Rat}
GHRH receptor GHRHR
Ghrhr
Ghrhr
Glucagon receptor family gastric inhibitory polypeptide {Sp: Human} , gastric inhibitory polypeptide {Sp: Mouse} , gastric inhibitory polypeptide {Sp: Rat}
GIP receptor GIPR
Gipr
Gipr
Glucagon receptor family glucagon {Sp: Human, Mouse, Rat}
glucagon-like peptide 1-(7-37) {Sp: Human, Mouse, Rat}
glucagon-like peptide 1-(7-36) amide {Sp: Human, Mouse, Rat}
GLP-1 receptor GLP1R
Glp1r
Glp1r
Glucagon receptor family glucagon-like peptide 2 {Sp: Human}
glucagon-like peptide 2-(3-33) {Sp: Human}
glucagon-like peptide 2 {Sp: Mouse}
glucagon-like peptide 2-(3-33) {Sp: Mouse}
glucagon-like peptide 2 {Sp: Rat}
glucagon-like peptide 2-(3-33) {Sp: Rat}
GLP-2 receptor GLP2R
Glp2r
Glp2r
Glucagon receptor family glucagon {Sp: Human, Mouse, Rat}
glucagon receptor GCGR
Gcgr
Gcgr
Glucagon receptor family secretin {Sp: Human} , secretin {Sp: Mouse} , secretin {Sp: Rat}
secretin receptor SCTR
Sctr
Sctr
Parathyroid hormone receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Parathyroid hormone receptors PTH {Sp: Human} , PTH {Sp: Mouse} , PTH {Sp: Rat}
PTHrP-(1-36) {Sp: Human}
PTHrP {Sp: Human}
PTH1 receptor PTH1R
Pth1r
Pth1r
Other endogenous fragments of parathyroid hormone-related protein precursor are PTHrP-(107-139) (human)/PTHrP-(107-139) (mouse)/PTHrP-(107-139) (rat) and PTHrP-(38-94).
Parathyroid hormone receptors PTH {Sp: Human} , PTH {Sp: Mouse} , PTH {Sp: Rat}
PTHrP-(1-36) {Sp: Human}
TIP39 {Sp: Human, Bovine} , TIP39 {Sp: Mouse, Rat}
PTH2 receptor PTH2R
Pth2r
Pth2r
PTH is a weak partial agonist in rat. PTHrP has very low efficacy. Other endogenous fragments of parathyroid hormone-related protein precursor are PTHrP-(107-139) (human)/PTHrP-(107-139) (mouse)/PTHrP-(107-139) (rat) and PTHrP-(38-94).
VIP and PACAP receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
VIP and PACAP receptors PACAP-38 {Sp: Human, Mouse, Rat}
PACAP-27 {Sp: Human, Mouse, Rat, Sheep}
PHI {Sp: Mouse, Rat}
PHM {Sp: Human}
PHV {Sp: Human} , PHV {Sp: Rat}
VIP {Sp: Human, Mouse, Rat}
PAC1 receptor ADCYAP1R1
Adcyap1r1
Adcyap1r1
PACAP-27 and PACAP-38 are the principal endogenous agonists
VIP and PACAP receptors GHRH {Sp: Human} , GHRH {Sp: Mouse} , GHRH {Sp: Rat}
PACAP-38 {Sp: Human, Mouse, Rat}
PACAP-27 {Sp: Human, Mouse, Rat, Sheep}
PHI {Sp: Mouse, Rat}
PHV {Sp: Rat}
secretin {Sp: Human} , secretin {Sp: Mouse} , secretin {Sp: Rat}
VIP {Sp: Human, Mouse, Rat}
VPAC1 receptor VIPR1
Vipr1
Vipr1
VIP, PACAP-27 and PACAP-38 are the principal endogenous agonists
VIP and PACAP receptors GHRH {Sp: Human} , GHRH {Sp: Mouse} , GHRH {Sp: Rat}
PACAP-38 {Sp: Human, Mouse, Rat}
PACAP-27 {Sp: Human, Mouse, Rat, Sheep}
PHI {Sp: Mouse, Rat}
PHV {Sp: Rat}
secretin {Sp: Human} , secretin {Sp: Mouse} , secretin {Sp: Rat}
VIP {Sp: Human, Mouse, Rat}
VPAC2 receptor VIPR2
Vipr2
Vipr2
VIP, PACAP-38 and PACAP-27 are the principal endogenous agonists