exendin-4

Ligand id: 1135

Name: exendin-4

Classification
Compound class Peptide or derivative
Approved drug? Yes (FDA (2005), EMA (2006))
International Nonproprietary Names
INN number INN
8219 exenatide
Synonyms
AC 2993 | AC002993 | AC2993A | Bydureon® | Byetta®
Database Links
BindingDB Ligand 50241203
CAS Registry No. 141758-74-9 (source: Scifinder)
ChEBI CHEBI:64073
ChEMBL Ligand CHEMBL414357
DrugBank Ligand DB01276
GtoPdb PubChem SID 135652150
PubChem CID 16157882
Search PubMed clinical trials exenatide
Search PubMed titles exenatide
Search PubMed titles/abstracts exenatide
UniProtKB P26349 (Hsu)
Wikipedia Exenatide
Comments
This peptide is found in the venom of the Gila monster Heloderma suspectum. Exenatide is the synthetic form of the peptide used in clinical practice. Exendin-4 is a GLP-1 analogue/mimetic [1]. There is some ambiguity surrounding the exact stereochemistry of exendin-4. Representations of the peptide's full chemical structure can be viewed using the PubChem, ChEMBL and ChEBI links above.