PACAP-38   Click here for help

GtoPdb Ligand ID: 2258

Synonyms: pituitary adenylate cyclase activating polypeptide-38
Compound class: Endogenous peptide in human, mouse or rat
Comment: Sequences of human, mouse, rat and sheep PACAP-38 are identical.

PACAP-38 has been proposed as a novel target for the teament of migraine [6]. In response, Alder BioPharmaceuticals have developed an anti-PACAP-38 monoclonal antibody (ALD1910) that has progressed to clinical evaluation (NCT04197349).
Species: Human, Mouse, Rat
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Neuropeptides
Synonyms Click here for help
pituitary adenylate cyclase activating polypeptide-38
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
ADCYAP1 adenylate cyclase activating polypeptide 1 Human prepro-PACAP adenylate cyclase activating polypeptide 1 (pituitary), PACAP
Adcyap1 adenylate cyclase activating polypeptide 1 Mouse prepro-PACAP PACAP
Adcyap1 adenylate cyclase activating polypeptide 1 Rat prepro-PACAP adenylate cyclase activating polypeptide 1, adenylate cyclase activating polypeptide 1 (pituitary), Pacap, pituitary adenylate cyclase-activating polypeptide, pituitary adenylate cyclase activating polypeptide 1, pituitary adenylate cyclase-activating polypeptide precursor (Pacap), rat pituitary adenylate cyclase activating polypeptide 1
Database Links Click here for help
Specialist databases
GPCRdb Ligand PACAP-38
Other databases
Ensembl Gene ENSG00000141433 (Hs), ENSMUSG00000024256 (Mm), ENSRNOG00000049882 (Rn)
GtoPdb PubChem SID 135651850
Human Protein Atlas ENSG00000141433 (Hs)
UniProtKB O70176 (Mm), P18509 (Hs), P13589 (Rn)