terfenadine

Ligand id: 2608

Name: terfenadine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 43.7
Molecular weight 471.31
XLogP 10.9
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (source: FDA)
Withdrawn drug? Yes
IUPAC Name
1-(4-tert-butylphenyl)-4-[4-[hydroxy-di(phenyl)methyl]piperidin-1-yl]butan-1-ol
International Nonproprietary Names
INN number INN
3674 terfenadine
Synonyms
RMI-9918
Seldane®
Triludan®
Database Links
BindingDB Ligand 50017376
CAS Registry No. 50679-08-8
ChEBI CHEBI:9453
ChEMBL Ligand CHEMBL17157
DrugBank Ligand DB00342
PharmGKB Drug PA451619
PubChem CID 5405
Search Google for chemical match using the InChIKey GUGOEEXESWIERI-UHFFFAOYSA-N
Search Google for chemicals with the same backbone GUGOEEXESWIERI
Search PubMed clinical trials terfenadine
Search PubMed titles terfenadine
Search PubMed titles/abstracts terfenadine
Wikipedia Terfenadine
Comments
Due to adverse effects on cardiac function, terfenadine has largely been superseded by fexofenadine. Terfenadine was completely withdrawn in the US in 1998.