CXCL13

Ligand id: 3645

Name: CXCL13

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Chemokines
Synonyms
BCA-1
Comments
CXCL13 is a C-X-C motif homeostatic chemokine that is selectively chemotactic for B cells belonging to both the B-1 and B-2 subsets. It exerts its biological effects via binding to the chemokine receptor CXCR5. CXCL13 expression can be regulated by the lymphotoxin β receptor (LTBR) pathway, and it contributes to ectopic tertiary lymphoid tissue development at sites of chronic inflammation in several autoimmune diseases, for example in the lacrimal and salivary glands of Sjögren's patients [4]. The CXCL13/LTBR axis is considered as a potential therapeutic target in conditions like Sjögren's syndrome. This is evidenced by the development of pharmaceutical agents that block LTBR activity being advanced to clinical trials (e.g. baminercept (BG9924) which is a soluble LTBR-IgG Fc fusion protein [3]).
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
CXCL13 C-X-C motif chemokine ligand 13 Human chemokine (C-X-C motif) ligand 13 ANGIE, ANGIE2, BCA-1, B-cell chemoattractant, BLC, BLR1L, chemokine (C-X-C motif) ligand 13, SCYB13, small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant)
Database Links
Ensembl Gene ENSG00000156234 (Hs)
GtoPdb PubChem SID 135651710
Human Protein Atlas ENSG00000156234 (Hs)
OMIM 605149 (Hs)
RefSeq Protein NP_006410 (Hs)
UniProtKB O43927 (Hs)
Wikipedia CXCL13 (Hs)