ambrisentan

Ligand id: 3951

Name: ambrisentan

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 81.54
Molecular weight 378.16
XLogP 6.66
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (source: FDA (2007), EMA (2008))
IUPAC Name
(2S)-2-(4,6-dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-di(phenyl)propanoic acid
International Nonproprietary Names
INN number INN
8128 ambrisentan
Synonyms
Letairis®
Database Links
CAS Registry No. 177036-94-1 (source: Scifinder)
ChEBI CHEBI:254051
ChEMBL Ligand CHEMBL1111
PubChem CID 6918493
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Wikipedia Ambrisentan
Comments
Ambrisentan is an endothelin receptor antagonist, with selectivity for the type A endothelin receptor (ETA).