CXCL12α

Ligand id: 4358

Name: CXCL12α

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
CXCL12 C-X-C motif chemokine ligand 12 Human chemokine (C-X-C motif) ligand 12 chemokine (C-X-C motif) ligand 12, PBSF, SCYB12, SDF1, SDF-1a, SDF1A, SDF-1b, SDF1B, stromal cell-derived factor 1, TLSF-a, TLSF-b, TPAR1
Synonyms
CXCL12 α
SDF-1α
stromal cell-derived factor-1α
Database Links
Ensembl Gene ENSG00000107562
Entrez Gene 6387
UniProtKB P48061 (Hs)
Wikipedia Stromal_cell-derived_factor-1
Comments
CXCL12-1α and β were the first isoforms of this chemokine identified. Both proteins contain a signal peptide sequence that medaites their secretion via the canonical intracellular secretory pathway. CXCL12 participates in a variety of processes central to homeostasis and physiology, exerting its biological effects by binding to the chemokine receptors CXCR4 and CXCR7.