adalimumab

Ligand id: 4860

Name: adalimumab

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Classification
Compound class Antibody
Approved drug? Yes (FDA (2002), EMA (2003))
International Nonproprietary Names
INN number INN
7860 adalimumab
Synonyms
D2E7 [5] | FKB327 | Humira®
Comments
Adalimumab is an anti-TNFα monoclonal antibody with immunosuppresive activity [5]. It was the first fully human monoclonal antibody drug approved by the FDA.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.

Biosimilars:
NameTrade nameCompanyClinical PhaseIndicationsReferences
adalimumab-atto; ZRC-3197 [1]AmjevitaAmgenApproved (2016 FDA)As per reference agent[3]
adalimumab-adbm; BI 695501CyltezoBoehringer IngelheimApproved (2017 FDA and EMA)As per reference agent 
adalimumab beta; ABP 501 AmgenPh 3 (NCT01970475)Rheumatoid arthritis 
SB5 Samsung BioepisPh 3 (NCT02167139)Rheumatoid arthritis 
BCD-057 BiocadPh 3 (NCT02762955)Plaque psoriasis 
GP2017 SandozPh 3 (NCT02016105)Plaque psoriasis, ankylosing spondylitis, rheumatoid arthritis  
M923 Momenta PharmaceuticalsPh 3 (NCT02581345)Plaque psoriasis, rheumatoid arthritis  
MYL-1401A MylanPh 3 (NCT02714322)Psoriasis, psoriatic arthritis 
MSB11022 MerckPh 3 (NCT02660580)Plaque psoriasis, rheumatoid arthritis  
PF-06410293 PfizerPh 3 (NCT02480153)Rheumatoid arthritis 
FKB327 Fujifilm Kyowa Kirin BiologicsPh 3 (NCT02260791)Rheumatoid arthritis[6]
IBI303 Innovent BiologicsPh 3 (NCT02893254)Active ankylosing spondylitis
Database Links
Specialist databases
IMGT/mAb-DB 165
Other databases
GtoPdb PubChem SID 178101561
PubChem SID 178101561
Search PubMed clinical trials adalimumab
Search PubMed titles adalimumab
Search PubMed titles/abstracts adalimumab
Wikipedia Adalimumab