Ligand id: 5012

Name: insulin

Species: Human

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View more information in the IUPHAR Pharmacology Education Project: insulin

Compound class Endogenous peptide in human, mouse or rat
Approved drug? Yes (FDA (1982))
International Nonproprietary Names
INN number INN
5186 insulin human
Database Links
Specialist databases
IMGT/mAb-DB 707
Other databases
DrugBank Ligand DB00030
Ensembl Gene ENSG00000254647 (Hs)
GtoPdb PubChem SID 178101709
Human Protein Atlas ENSG00000254647 (Hs)
Search PubMed clinical trials insulin human
Search PubMed titles insulin human
Search PubMed titles/abstracts insulin human
UniProtKB P01308 (Hs)
Wikipedia Insulin
The biologically active peptide is a heterodimer of an A chain and a B chain linked by two disulphide bonds. The structure of approved drug insulin regular (which the link to DrugBank outlines) is identical to native human insulin.

While recombinant human insulin was approved by the FDA in 1982, insulin from pigs was used for several decades prior to this date.