Ligand id: 573

Name: C5a

Species: Human

Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Complement components and ligands
Gene symbol Gene name Species Precursor protein name Synonyms
C5 complement C5 Human prepro-C5 complement component 5, CPAMD4
C5a anaphylatoxin | complement component C5a | human complement protein
Database Links
CAS Registry No. 80295-54-1 (Hs)
DrugBank Target P01031 (Hs)
GtoPdb PubChem SID 135651643
UniProtKB P01031 (Hs)
Wikipedia Complement_component_5a
C5a is the ligand for the GPCR, C5a receptor (CD88) that is expressed by macrophages, neutrophils and endothelial cells. C5a is a potent inflammatory agent that is a key mediator involved in the pathogenesis of a number of inflammatory diseases involving the complement system (sepsis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythemotosis and psoriasis for example).