Akt inhibitor X

Ligand id: 5922

Name: Akt inhibitor X

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 7
Topological polar surface area 15.71
Molecular weight 344.17
XLogP 5.33
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
[4-(2-chloro-10H-phenoxazin-10-yl)butyl]diethylamine
Synonyms
10-DEBC | NCGC00167772-01
Database Links
CAS Registry No. 201788-90-1
ChEMBL Ligand CHEMBL1398474
PubChem CID 10521421
RCSB PDB Ligand RTX
Search Google for chemical match using the InChIKey GYBXAGDWMCJZJK-UHFFFAOYSA-N
Search Google for chemicals with the same backbone GYBXAGDWMCJZJK
Search UniChem for chemical match using the InChIKey GYBXAGDWMCJZJK-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone GYBXAGDWMCJZJK
SynPHARM 80328 (in complex with Pim-1 proto-oncogene, serine/threonine kinase)
Comments
This is compound 10B in [4] which describes its actions as an Akt (aka protein kinase B) inhibitor.
This compound is a thioridazine derivative. Thioridazine is a well known antipsychotic that acts as an antagonist of dopamine receptor activity. The compound also inhibits the kinase activity of Pim-1 [3] and X-ray crystallography shows the compound binding to the Pim-1 pharmacophore.