cilazapril

Ligand id: 6459

Name: cilazapril

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 99.18
Molecular weight 417.23
XLogP 4.19
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes
Withdrawn drug? Yes
Is prodrug? Yes
Active form cilazaprilat
IUPAC Name
(1S,9S)-9-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-10-oxo-1,2,3,4,6,7,8,9-octahydropyridazino[1,2-a]diazepine-1-carboxylic acid
International Nonproprietary Names
INN number INN
5675 cilazapril
Synonyms
Inhibace® | Ro 31-2848006 | Vascace®
Database Links
CAS Registry No. 88768-40-5
ChEMBL Ligand CHEMBL515606
DrugBank Ligand DB01340
PubChem CID 56330
Search Google for chemical match using the InChIKey HHHKFGXWKKUNCY-FHWLQOOXSA-N
Search Google for chemicals with the same backbone HHHKFGXWKKUNCY
Search PubMed clinical trials cilazapril
Search PubMed titles cilazapril
Search PubMed titles/abstracts cilazapril
Search UniChem for chemical match using the InChIKey HHHKFGXWKKUNCY-FHWLQOOXSA-N
Search UniChem for chemicals with the same backbone HHHKFGXWKKUNCY
Wikipedia Cilazapril
Comments
Cilazapril is a prodrug. It is metabolically converted to the drug cilazaprilat. Cilazapril does not appear to have marketing approval for human use in the US or EU, although national approval agencies may have granted marketing authorisation.