dabrafenib

Ligand id: 6494

Name: dabrafenib

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 147.48
Molecular weight 519.1
XLogP 4.79
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (source: FDA and EMA (2013))
IUPAC Name
N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
International Nonproprietary Names
INN number INN
9458 dabrafenib
Synonyms
GSK2118436 | GSK2118436A | Tafinlar®
Database Links
CAS Registry No. 1195765-45-7 (source: SciFinder)
ChEMBL Ligand CHEMBL2028663
DrugBank Ligand DB08912
PubChem CID 44462760
RCSB PDB Ligand P06
Search Google for chemical match using the InChIKey BFSMGDJOXZAERB-UHFFFAOYSA-N
Search Google for chemicals with the same backbone BFSMGDJOXZAERB
Search PubMed clinical trials dabrafenib
Search PubMed titles dabrafenib
Search PubMed titles/abstracts dabrafenib
Search UniChem for chemical match using the InChIKey BFSMGDJOXZAERB-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone BFSMGDJOXZAERB
SynPHARM 79043 (in complex with B-Raf proto-oncogene, serine/threonine kinase)
Wikipedia Dabrafenib
Comments
Dabrafenib is a Type-1.5 kinase inhibitor.