cilengitide

Ligand id: 6597

Name: cilengitide

Structure and Physico-chemical Properties

2D Structure
Classification
Compound class Peptide or derivative
IUPAC Name
2-[(2S,5R,8S,11S)-11-[3-(diaminomethylideneamino)propyl]-7-methyl-3,6,9,12,15-pentaoxo-5-(phenylmethyl)-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid
International Nonproprietary Names
INN number INN
7823 cilengitide
Synonyms
EMD-12192
EMD-121974
Database Links
CAS Registry No. 188968-51-6
ChEMBL Ligand CHEMBL429876
PubChem CID 176873
Search Google for chemical match using the InChIKey AMLYAMJWYAIXIA-VWNVYAMZSA-N
Search Google for chemicals with the same backbone AMLYAMJWYAIXIA
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Wikipedia Cilengitide
Comments
Cilengitide is a pentapeptide, first-in-class integrin inhibitor. It inhibits integrin αv-induced angiogenesis. It was investigated for anti-tumour activity. Glioblastoma was one of the cancers investigated [5], based on encouraging preclinical studies in animals [3-4,6].