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|Approved drug?||Yes (source: FDA (2006), EMA (2007))|
|International Nonproprietary Names|
|Fab-12 variant Y0317|
|muMAb VEGF A.4.6.1|
|Search PubMed clinical trials||ranibizumab|
|Search PubMed titles||ranibizumab|
|Search PubMed titles/abstracts||ranibizumab|
|Ranibizumab is a Fab fragment of a monoclonal antibody designed to target vascular endothelial growth factor A (VEGFA).
Annotated peptide sequences for this antibody derivative are available from its IMGT/mAb-DB record.
Peptide sequence analysis reveals that ranibizumab sequences are claimed in patent WO1998045331 (clone Y0317) , with an expected affinity similar to clone Y0313-1. It is the Fab fragment of bevacizumab.