clofarabine

Ligand id: 6802

Name: clofarabine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 119.31
Molecular weight 303.05
XLogP -0.55
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (source: FDA (2004), EMA (2009))
IUPAC Name
(2R,3R,4S,5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
International Nonproprietary Names
INN number INN
8422 clofarabine
Synonyms
CAFdA | Cl-F-araA | Clolar® | Evoltra®
Database Links
CAS Registry No. 23318-82-1
ChEMBL Ligand CHEMBL1750
DrugBank Ligand DB00631
PubChem CID 119182
RCSB PDB Ligand CFB
Search Google for chemical match using the InChIKey WDDPHFBMKLOVOX-AYQXTPAHSA-N
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Search UniChem for chemical match using the InChIKey WDDPHFBMKLOVOX-AYQXTPAHSA-N
Search UniChem for chemicals with the same backbone WDDPHFBMKLOVOX
Wikipedia Clofarabine
Comments
A DNA polymerase (α/δ/ε) inhibitor, DNA and ribonucleoside-diphosphate reductase (RR1) inhibitor.