teduglutide

Ligand id: 7049

Name: teduglutide

Classification
Compound class Peptide or derivative
Approved drug? Yes (FDA and EMA (2012))
International Nonproprietary Names
INN number INN
8444 teduglutide
Synonyms
ALX-0600 | Gattex® | GLP2-2G | Revestive®
Comments
Teduglutide is a glucagon-like peptide-2 (GLP-2) analogue in which position 2 amino acid alanine is replaced by glycine, increasing the peptide's resistance to proteolytic cleavage by dipeptidyl peptidase-4 (DPP-4) [2]. The chemical structure of teduglutide is represented in the PubChem and ChEMBL entries listed below. The intestinotrophic effects of GLP-2 (e.g. promotion of intestinal growth, reduced epithelial cell apoptosis and inflammation) has led to the development of GLP-2 analogues like teduglutide for the treatment of GI disorders such as short bowel syndrome and inflammatory bowel diseases.
Database Links
Specialist databases
IMGT/mAb-DB 710
Other databases
CAS Registry No. 197922-42-2
ChEMBL Ligand CHEMBL2104987
DrugBank Ligand DB08900
GtoPdb PubChem SID 178103628
PubChem CID 16139605
Search PubMed clinical trials teduglutide
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Wikipedia Teduglutide