Ligand id: 7341

Name: ataluren

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 76.22
Molecular weight 284.06
XLogP 4.49
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Compound class Synthetic organic
Approved drug? Yes (source: EMA (2014))
3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid
International Nonproprietary Names
INN number INN
8956 ataluren
Database Links
CAS Registry No. 775304-57-9 (source: SciFinder)
ChEMBL Ligand CHEMBL256997
PubChem CID 11219835
Search Google for chemical match using the InChIKey OOUGLTULBSNHNF-UHFFFAOYSA-N
Search Google for chemicals with the same backbone OOUGLTULBSNHNF
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Wikipedia Ataluren
Ataluren is a compound in an emerging class of chemicals which induce ribosomal readthrough. This developing pharmaceutical intervention has been termed 'readthrough strategy'. Clinically, this type of compound has potential benefit in the treatment of genetic disorders associated with loss of functional protein due to nonsense or PTC mutations, such as certain types of muscular dystrophy, cystic fibrosis and many cancers [1,4].