IMCgp100

Ligand id: 7378

Name: IMCgp100

Classification
Compound class Antibody
Database Links
PubChem SID 178103950
Comments
IMCgp100 is an immunotherapeutic antibody/peptide fusion, comprising a soluble T cell receptor (TCR) specific for the HLA-A2 restricted melanoma-associated antigen gp100, fused to an anti-CD3 single chain antibody fragment (scFv) [1,3]. This belongs to a novel class of immunotherapeutics termed ImmTACs (Immune Mobilising mTCR against Cancer) which are designed to override immune tolerance to cancer and mobilise T cells to kill cancer cells.