carfilzomib

Ligand id: 7420

Name: carfilzomib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 12
Hydrogen bond donors 4
Rotatable bonds 24
Topological polar surface area 158.47
Molecular weight 719.43
XLogP 7.56
No. Lipinski's rules broken 3

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (2012))
IUPAC Name
(2S)-4-methyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide
International Nonproprietary Names
INN number INN
8859 carfilzomib
Synonyms
Kyprolis® | PR-171
Database Links
CAS Registry No. 868540-17-4
ChEMBL Ligand CHEMBL451887
DrugBank Ligand DB08889
PubChem CID 11556711
Search Google for chemical match using the InChIKey BLMPQMFVWMYDKT-NZTKNTHTSA-N
Search Google for chemicals with the same backbone BLMPQMFVWMYDKT
Search PubMed clinical trials carfilzomib
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Search UniChem for chemical match using the InChIKey BLMPQMFVWMYDKT-NZTKNTHTSA-N
Search UniChem for chemicals with the same backbone BLMPQMFVWMYDKT
Wikipedia Carfilzomib
Comments
Carfilzomib is a tetrapeptide analogue of epoxomicin, an Actinomycete derived selective proteasome inhibitor [1].