Ligand id: 7541

Name: ixekizumab

Compound class Antibody
Approved drug? Yes (FDA & EMA (2016))
International Nonproprietary Names
INN number INN
9467 ixekizumab
LY-2439821 | Taltz®
Database Links
Specialist databases
IMGT/mAb-DB 380
Other databases
GtoPdb PubChem SID 187051842
PubChem SID 187051842
Search PubMed clinical trials ixekizumab
Search PubMed titles ixekizumab
Search PubMed titles/abstracts ixekizumab
Wikipedia Ixekizumab
Ixekizumab binds to IL-17A and blocks its action.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record. A protein BLAST search using the variable region of the heavy chain of ixekizumab identifies this as sequence 118 from patent US7838638 [1]. In this patent binding affinity data for human IL-17 is provided for several antibody clones, but it does not specify which was chosen as ixekizumab, although mAbs 126, 121 and 104 did undergo additional experimental investigations.