CD274

Ligand id: 7693

Name: CD274

Abbreviated name: PD-L1

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
CD274 CD274 molecule Human -
Synonyms
B7 homolog 1
B7-H1
PDCD1LG1
programmed cell death 1 ligand 1
Database Links
UniProtKB Q9NZQ7 (Hs)
Wikipedia PD-L1
Comments
PD-L1 is an important immunopharmacological drug discovery target., as many types of cancer cells express this ligand [1-2,5]. Expression of cell-surface PD-L1 permits malignant cells to 'evade' destruction by the immune system by inhibiting T-cell-mediated responses. Antibodies directed against PD-L1 are emerging as novel cancer therapeutics. This list of clinical trials assessing MPDL3280A, just one ant-PD-L1 agent, gives an idea of the range of cancers that may respond to this mechanism of drug action. See also [4] and [3].