amatuximab

Ligand id: 7750

Name: amatuximab

Classification
Compound class Antibody
International Nonproprietary Names
INN number INN
9343 amatuximab
Synonyms
MORAb-009
Database Links
Specialist databases
IMGT/mAb-DB 64
Other databases
Search PubMed clinical trials amatuximab
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Wikipedia Amatuximab
Comments
Amatuximab is a chimeric monoclonal antibody to mesothelin (MSLN; Q13421), a cell surface glycoprotein highly expressed in malignant pleural mesothelioma, all pancreatic adenocarcinoma, the majority of ovarian adenocarcinoma, as well as in non-small cell lung and colorectal cancers[5].
The crystal structure of the Fab fragment of amatuximab in complex with a mesothelin fragment (amino acids 7-64) has been deposited in Protein Data Bank with accession 4F33 [4].