AKN-028

Ligand id: 7969

Name: AKN-028

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 3
Topological polar surface area 92.51
Molecular weight 302.13
XLogP 2.06
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
3-N-(1H-indol-5-yl)-5-pyridin-4-ylpyrazine-2,3-diamine
Synonyms
AKN 028
AKN028
Database Links
CAS Registry No. 1175017-90-9
PubChem CID 44177328
Search Google for chemical match using the InChIKey JLRIJKVMMZEKDF-UHFFFAOYSA-N
Search Google for chemicals with the same backbone JLRIJKVMMZEKDF
Comments
AKN-028 is an orally bioavailable protein tyrosine kinase inhibitor for FMS-related tyrosine kinase 3 (FLT3) and stem cell factor receptor (SCFR; KIT), with potential antineoplastic activity [1-2]. The compound inhibits wild-type and mutant FLT3 and KIT kinases.