pemtumomab

Ligand id: 8031

Name: pemtumomab

Classification
Compound class Antibody
Synonyms
Names References
HMFG1
HuHMFG-1 2
Database Links
Wikipedia Pemtumomab
Comments
Pemtumomab is a monoclonal antibody directed against a specific antigenic epitope (PDTR sequence in the MUC1 tandem repeat [5]) of the mucin 1 (MUC1) expressed by several types of secretory epithelial-derived cancers [4]. MUC1 is a large, heavily glycosylated mucin. It is expressed on the apical surface of the most secretory epithelial cells [1] and an antigenically distinct form of MUC1 is overexpressed in 90% of adenocarcinomas, including cancers of the ovary, breast, and pancreas. This means that antibodies can be targeted to cancerous cells [3,5], sparing normal tissue. Pemtumomab is labelled with the radioisotope yttrium-90.
This antibody does not appear to have an INN (international non-proprietary name), and no peptide sequences are available.