AGK2

Ligand id: 8099

Name: AGK2

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 78.92
Molecular weight 433.04
XLogP 5.57
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(E)-2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-quinolin-5-ylprop-2-enamide
Synonyms
AGK 2 | AGK-2
Database Links
CAS Registry No. 304896-28-4
ChEMBL Ligand CHEMBL224864
PubChem CID 2130404
Search Google for chemical match using the InChIKey SVENPFFEMUOOGK-SDNWHVSQSA-N
Search Google for chemicals with the same backbone SVENPFFEMUOOGK
Search UniChem for chemical match using the InChIKey SVENPFFEMUOOGK-SDNWHVSQSA-N
Search UniChem for chemicals with the same backbone SVENPFFEMUOOGK
Comments
AGK2 is a selective sirtuin 2 (SIRT2) inhibitor [3]. The sirtuins are members of the histone deacetylase family.
The SIRT histone deacetylases have been implicated in a wide range of cellular processes including stress resistance, metabolism, differentiation, and aging [1].