CXCL8   Click here for help

GtoPdb Ligand ID: 821

Synonyms: interleukin-8
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: The CXCL8 (IL-8) chemokine is upregulated at sites of inflammation where it promotes neutrophil infiltration and activation. It can form homodimers and heterodimers with CXCL4.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Chemokines
Synonyms Click here for help
interleukin-8
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
CXCL8 C-X-C motif chemokine ligand 8 Human interleukin 8 3-10C, alveolar macrophage chemotactic factor I, AMCF-I, b-ENAP, beta endothelial cell-derived neutrophil activating peptide, chemokine (C-X-C motif) ligand 8, CXCL8, GCP-1, GCP1, granulocyte chemotactic protein 1, IL-8, IL8, interleukin 8, K60, LECT, LUCT, lung giant cell carcinoma-derived chemotactic protein, lymphocyte derived neutrophil activating peptide, LYNAP, MDNCF, MONAP, monocyte-derived neutrophil-activating peptide, monocyte-derived neutrophil chemotactic factor, NAF, NAP-1, NAP1, neutrophil-activating peptide 1, SCYB8, TSG-1, tumor necrosis factor-induced gene 1
Database Links Click here for help
Specialist databases
GPCRdb Ligand CXCL8
Other databases
Ensembl Gene ENSG00000169429 (Hs)
GtoPdb PubChem SID 135651725
Human Protein Atlas ENSG00000169429 (Hs)
Immunopaedia Search CXCL8
UniProtKB P10145 (Hs)
Wikipedia Interleukin_8