Ligand id: 8357

Name: LY3002813

Compound class Antibody
LY3002813 is a monoclonal antibody developed from the murine monoclonal mE8-IgG2a [1]. LY3002813 binds to N-terminally, pyroglutamate-modified amyloid β proteins (abbreviated as Aβp3-x) which are found extensively in the amyloid plaques of the brains of Alzheimer's disease (AD) patients. The removal of Aβp3-x is being investigated as a novel mechanism to treat AD. Both immunotherapy with the use of antibody clearance, and small molecule inhibition of the enzyme which catalyses the cyclisisation of N-terminal Aβ glutamate are being tested clinically.