MLS1547

Ligand id: 8369

Name: MLS1547

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 52.49
Molecular weight 354.12
XLogP 2.57
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
5-chloro-7-[(4-pyridin-2-ylpiperazin-1-yl)methyl]quinolin-8-ol
Synonyms
MLS000051547
Database Links
ChEMBL Ligand CHEMBL1606583
PubChem CID 1093278
Search Google for chemical match using the InChIKey OPEJNANYABTIGC-UHFFFAOYSA-N
Search Google for chemicals with the same backbone OPEJNANYABTIGC
Search UniChem for chemical match using the InChIKey OPEJNANYABTIGC-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone OPEJNANYABTIGC
Comments
MLS1547 is reported to be a G protein biased dopamine D2 receptor agonist [1]. The compound antagonises arrestin recruitment to the dopamine-induced D2 receptor, but behaves as an agonist in its capacity to induce G protein signalling (ie inhibition of cAMP accumulation via Gi).