codrituzumab

Ligand id: 8406

Name: codrituzumab

Classification
Compound class Antibody
International Nonproprietary Names
INN number INN
9759 codrituzumab
Synonyms
GC33
RG-7686
RG7686
RO-5137382
RO5137382
Database Links
Specialist databases
IMGT/mAb-DB 466
Other databases
Search PubMed clinical trials codrituzumab
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Comments
Codrituzumab is the first-in-class, recombinant, humanized monoclonal antibody which binds to glypican-3 (GPC3). GPC3 is an oncofetal protein highly expressed in hepatocellular carcinoma (HCC) cells [1,3-4]. The anti-GPC3 antibody has been modified to carry fewer fucose sugar chains with the aim of increasing its cytotoxic activity, and therefore improving its inhibitory effect on cell growth, providing an enhanced anticancer agent.
Peptide sequence information for this antibody is available from its IMGT/mAb-DB record. Peptide sequence match identifies US7867734 as the covering patent [2].