simtuzumab

Ligand id: 8412

Name: simtuzumab

Classification
Compound class Antibody
International Nonproprietary Names
INN number INN
9626 simtuzumab
Synonyms
AB0024
GS 6624
GS-6624
Database Links
Specialist databases
IMGT/mAb-DB 430
Other databases
Search PubMed clinical trials simtuzumab
Search PubMed titles simtuzumab
Search PubMed titles/abstracts simtuzumab
Wikipedia Simtuzumab
Comments
Simtuzumab is an investigational monoclonal antibody targeting lysyl oxidase-like 2 (LOXL2). The antibody is reported to be an allosteric modulator of LOXL2 enzymatic activity [6-7].
Peptide sequence information for this antibody is available from its IMGT/mAb-DB record. Peptide sequence matches reveal that US8461303 is the covering patent [7]. The heavy chain variable domain sequence of simtuzumab (from IMGT) matches the sequence for the AB0023 M20 variant 3 clone in US8461303.