margetuximab

Ligand id: 8686

Name: margetuximab

Classification
Compound class Antibody
International Nonproprietary Names
INN number INN
9799 margetuximab
Synonyms
MGAH-22
Database Links
Specialist databases
IMGT/mAb-DB 473
Other databases
Search PubMed clinical trials margetuximab
Search PubMed titles margetuximab
Search PubMed titles/abstracts margetuximab
Comments
Margetuximab is a chimeric monoclonal antibody targeting epidermal growth factor receptor 2 (ERBB2).
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record. Peptide sequence search of patented sequences reveals a 100% match between the heavy chain variable domain of margetuximab and SEQ ID NO: 13 from patent US8802093 B2, and antibody clone ch4D5-FcMT3 [1]. Although the patent describes performing Biacore assays to determine antibody-target (ERBB2) affinity, a KD value is not provided.