evinacumab

Ligand id: 8717

Name: evinacumab

Classification
Compound class Antibody
International Nonproprietary Names
INN number INN
10013 evinacumab
Synonyms
REGN1500
Database Links
Specialist databases
IMGT/mAb-DB 529
Other databases
GtoPdb PubChem SID 252827375
Search PubMed clinical trials evinacumab
Search PubMed titles evinacumab
Search PubMed titles/abstracts evinacumab
Comments
Evinacumab is a fully human investigational monoclonal antibody targeting angiopoietin-like 3 (ANGPTL3). Due to its role in lipid metabolism, ANGPTL3 is being investigated as a potential molecular target for the treatment of hypertriglyceridemia in cardiovascular disease.
Peptide sequence and structural information for this antibody are available from its IMGT/mAb-db record.
A BLAST search of patented peptide sequences reveals that the heavy chain variable domain of evinacumab is identical to SEQ ID: NO 66 from patent US9018356 B2 [3], and the light chain variable region is identical to SEQ ID: NO 74 from the same patent (this heavy/light chain combination corresponds to antibody identifier H4H1276S).