AMG-337

Ligand id: 8913

Name: AMG-337

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 131.25
Molecular weight 404.12
XLogP 2.56
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
7-methoxy-N-[[6-(3-methyl-1,2-thiazol-5-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl]-1,5-naphthyridin-4-amine
Synonyms
compound 24 [PMID: 19819693]
Database Links
BindingDB Ligand 50302905
ChEMBL Ligand CHEMBL566685
PubChem CID 45487870
RCSB PDB Ligand 0JJ
Search Google for chemical match using the InChIKey QMWKLCXWSJTEFT-UHFFFAOYSA-N
Search Google for chemicals with the same backbone QMWKLCXWSJTEFT
Search UniChem for chemical match using the InChIKey QMWKLCXWSJTEFT-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone QMWKLCXWSJTEFT
Comments
AMG-337 is an investigational inhibitor of the MET proto-oncogene receptor tyrosine kinase (a.k.a. hepatocyte growth factor receptor or c-MET). This compound has been designed to decrease its inhibitory effect on CYP3A4 metabolic activity (i.e. its liability of inhibiting hepatic drug metabolism) [1-2].