opicinumab

Ligand id: 8923

Name: opicinumab

Classification
Compound class Antibody
International Nonproprietary Names
INN number INN
10090 opicinumab
Synonyms
BIIB-033
BIIB033
Database Links
Search PubMed clinical trials opicinumab
Search PubMed titles opicinumab
Search PubMed titles/abstracts opicinumab
Comments
Opicinumab is a monoclonal antibody which acts as a functional antagonist of the neural protein, LINGO1 [1-2]. Opicinumab is being investigated for its clinical utility in diseases with underlying immune-driven demyelination.
Peptide sequence and structural information for this antibody are available from its IMGT/mAb-db record. A BLAST search of patented peptide sequences reveals a 100% match between the variable heavy chain region of opicinumab and SEQ ID NO: 5 from patent US8058406 B2, and another identical match between the variable light chain of the antibody and the patent's SEQ ID NO: 13 [1].