connective tissue growth factor

Ligand id: 8927

Name: connective tissue growth factor

Abbreviated name: CTGF

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
CTGF connective tissue growth factor Human connective tissue growth factor precursor CCN2, IGFBP8
Comments
CTGF is a multifunctional growth factor secreted by vascular endothelial cells. CTGF is involved in cell migration, proliferation, and differentiation, plays a role chondrogenesis and is involved in the modulation of extracellular matrix deposition and angiogenesis [1-4]. CTGF is expressed at high levels in several types of human malignancies.
CTGF is a clinical molecular target for the identification of therapeutics for the treatment of fibroproliferative diseases.
The signal peptide sequence is MTAASMGPVRVAFVVLLALCSRPAVG (1-26 of the full length amino acid sequence detailed here).