onartuzumab

Ligand id: 8966

Name: onartuzumab

Classification
Compound class Antibody
International Nonproprietary Names
INN number INN
9368 onartuzumab
Synonyms
MetMAb
OA-5D5
OA5D5
PRO 143966
Database Links
Specialist databases
IMGT/mAb-DB 368
Other databases
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Comments
Onartuzumab is an investigational, humanized monoclonal antibody targeting the MET receptor tyrosine kinase, a proto-oncogene which acts as a hepatocyte growth factor receptor. The protein is a monovalent (single-armed) construct, as opposed to bi-valent intact antibody structures.
Peptide sequence information for this antibody is available from its IMGT/mAb-DB record.
BLAST peptide analysis reveals identical match with sequences deposited with patent US7615529 [4], which relate to the monoclonal isolated from hybridoma 5D5.11.6 therein.