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Molecular properties generated using the CDK |
Classification ![]() |
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Compound class | Natural product or derivative |
Database Links ![]() |
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GtoPdb PubChem SID | 310264761 |
PubChem CID | 441082 |
Search Google for chemical match using the InChIKey | GPLGAQQQNWMVMM-MYAJQUOBSA-N |
Search Google for chemicals with the same backbone | GPLGAQQQNWMVMM |
Search UniChem for chemical match using the InChIKey | GPLGAQQQNWMVMM-MYAJQUOBSA-N |
Search UniChem for chemicals with the same backbone | GPLGAQQQNWMVMM |
Comments |
Conessine is an alkaloid obtained from the bark and seeds of Holarrhena antidysenterica trees. It binds with high affinity to rat and human histamine H3 receptors in radio-ligand binding assays, acting as a receptor antagonist [2-3]. H3 antagonists are being researched as potential drugs for the treatment of neurodegenerative conditions and for their stimulant and nootropic effects. For example, pitolisant is in clinical trial for Parkinson's disease, narcolepsy, cataplexy and excessive daytime sleepiness. |