FGF-23

Ligand id: 9291

Name: FGF-23

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Fibroblast growth factor (FGF) family ligands
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
FGF23 fibroblast growth factor 23 Human fibroblast growth factor 23 precursor -
Synonyms
fibroblast growth factor 23
Database Links
Ensembl Gene ENSG00000118972 (Hs)
Entrez Gene 8074 (Hs)
Human Protein Atlas ENSG00000118972 (Hs)
UniProtKB Q9GZV9 (Hs)
Wikipedia Fibroblast_growth_factor_23
Comments
FGF-23 regulates phosphate homeostasis and transport in the kidney [1]. The full-length 327 amino acid protein is functional, and is deactivated by proteolytic cleavage which generates N-terminal and C-terminal chains. Mutation of the cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR), and other gene alterations are associated with hyperphosphatemic familial tumoral calcinosis (HFTC). Antibody-driven inactivation of FGF-23 is being investigated as a pharmacological intervention in these indications. Burosumab (KRN23) is one such FGF-23 neutralising antibody in clinical development.